发育神经生物学【2025|PDF下载-Epub版本|mobi电子书|kindle百度云盘下载】

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第一章 机体发育过程中的基因表达及同源异形基因盒1

Chapter 1 Expression of Genes during Development and Homebox Gene1

Differentiation of Embryonic Cell2

胚胎细胞分化2

Expression of Genes during Development5

机体成形过程中的基因表达5

Specific Expression of Genes in Adult Tissue18

成体组织中基因的特异性表达18

Modulation of Genes in Cell Differentiation19

细胞分化的基因调控机制19

Homebox Gene and Developing Nervous System21

同源盒基因家族与神经系统发育21

第二章 神经细胞的发育分化与神经系统发育中的基因调控32

Chapter 2 Development and Differentiation of Neural Cells and Modulation of Genes in Developing Nerv32

Neuroepitheliurn in Cell Circle32

细胞周期中的神经上皮细胞32

中枢神经系统神经元与神经胶质细胞的起源与分化37

Origin and Differentiation of Neuron and Neuroglia in Central Nervous System37

Modulation of Genes in Developing Nervous System47

神经系统发育中的基因调控47

胚盘中轴结构的形成52

Formation of Axonal Structure in Embryonic Disk52

Chapter 3 Development of Nervous System52

第三章 神经系统的发生52

Developmental Model of Developing Nervous System53

神经系统发育分化的基本规律和模式53

神经诱导与分化决定54

Neural Indution and Determination54

细胞粘附分子与神经发育58

Neural Cell Adhesion Molecule and Neural Development58

Morphogenesis of Nervous System60

神经系统的发生60

Chapter 4 Axonal Development76

第四章 轴突的发育76

细胞骨架77

The Cytoskeleton77

轴突运输83

Axonal Transport83

生长锥86

The Growth Cone86

Outgrowth of the Axon89

轴突的长出89

Single Transduction during Axonal Growth95

轴突生长发育过程中的信息转导95

Chapter 5 Dendritic Development and Formation of Synaptic Connections98

第五章 树突的发育和突触的形成98

Outgrowth of Dendrite99

树突的生长发育99

树突发育的时空规律101

Time and Spatial Regulation of Developing Dendrite101

Morphology of Dendritic Growth Cone102

Morphology and Function of Dendritic Spine102

树突生长锥的形态结构102

树突棘的结构和功能102

Cytochrome Oxidase Activity of Dendrite105

树突的细胞色素氧化酶活性105

Factors Influencing Growth of Dendrite106

影响树突生长发育的一些因素106

树突发育的稳定性108

Developmental Stability of Dendrite108

突触形成的一般概述109

Introduction of Synaptic Formation109

Program of Synaptic Formation111

突触形成的程序性111

Ultrastructural Defferentiation of Synapses113

突触超微结构的分化113

突触连接的地域分布特异性115

突触的稳定性和适应性115

Synaptic Stability and Lability115

Topographical Specificity of Synaptic Connection115

视觉刺激和视觉剥夺对突触形成的影响116

Effects of Visual Stimultion and Deprivation on Formation of Synaptic Connection116

蛋白质聚集素在突触形成中的作用117

Role of Argine in Synapse Formation117

概论120

第六章 神经嵴及其衍生物120

Introduction120

Chapter 6 The Neural Crest and Its Derivatives120

Developmental Process of Nreural Crest124

神经嵴的发育过程124

Basic Patterns of Neural Crest Development133

神经嵴发育的基本方式133

Factors Regulating Development and Differentiation of Neural Crest and Its Derivatives134

神经嵴及其衍生物分化发育的调控因素134

Regulating Model of Migration of Neural Crest Cells136

神经嵴细胞迁移的调节模式136

Control of Differentiation of Neural Crest Cells137

神经嵴细胞分化的调控137

脊髓感觉通路的胚胎发生及调控因素138

Histogenesis of Spinal Sensory Pathway and Its Regulating Factors138

Chapter 7 Neuroglial Cells142

第七章 神经胶质细胞142

Origin and Differentiation of CNS Macroglial Cells144

中枢大胶质细胞的起源和分化144

Astrocytes145

星形胶质细胞145

少突胶质细胞156

Oligodendrocytes156

小胶质细胞163

Microglial Cells163

Chapter 8 Histogenesis of Cerebral Neocortex171

Schwann Cells171

雪旺细胞171

第八章 大脑新皮质的组织发生177

Development of Cerebral Cortex:Overview177

大脑皮质发育概况177

Developmental Pattem of Ancestor Cells in Ventricular Zone of Telencephalon178

端脑脑室层祖细胞的发生规律178

Formation of the Cortical Preplate181

早期胚胎皮质板的发生181

大脑新皮质板层的组织发生185

Histogenesis of Cerebral Cortical Plate185

大脑皮质传入神经纤维的发生188

Development of Cerebral Cortical Afferent Nerve Fibers188

大脑皮质传出神经纤维的发生191

Development of Cerebral Cortical Efferent Nerve Fibers191

大脑皮质功能单位的发育192

Development of Functional Units in Cerebral Cortex192

视皮质神经回路的发生196

Histogenesis of Neural-Circuit in the Optic Tecturn196

General Overview of Retinal Canglion Cells201

第九章 视网膜节细胞发育201

视网膜节细胞概况201

Chapter 9 Development of Retinal Ganglion Cells201

视网膜节细胞的密度和分布202

Density and Distribution of Retinal Ganglion Cells202

视网膜节细胞的分类203

Classification of Retinal Ganglion Cells203

Arrangement of Dendrites of Retinal Ganglion Cells208

视网膜节细胞树突的分层208

视网膜节细胞的分化和发育208

Development and Differentiation of Retinal Ganglion Cells208

视网膜节细胞轴突投射的发育212

Development of Axon Projections of Retinal Ganglion Cells212

历史回顾221

Historical Overview221

Chapter 10 Programmed Neuronal Death and Its Occurring Mechanisms during Development221

第十章 发育过程中的神经细胞编程性死亡及其发生机理221

细胞凋亡的形态学与生化特征222

Morpbological and Biochemical Characteristics of Cell Apoptosis222

神经细胞编程性死亡的生物学意义227

Biological Significance of Programmed Neuronal Death227

神经细胞编程性死亡的发生机理229

Occurring Mechanisms of Programmed Neuronal Death229

细胞周期与细胞凋亡238

Cell Cycle and Cell Apoptosis238

老化与发育：对立的统一243

Aging and Development;Opposite Unity243

第十一章 脑的老化与老年性痴呆243

Chapter 11 Brain Aging and Senile Dementia243

脑的老化246

Aging of Brain246

生理性脑老化与老年性痴呆250

Physiological Aging of Brain and Dementia250

推迟脑衰老的对策253

Counter Tactics of Postpone the Aging of Brain253

Chapter 12 Neurotrophic Factors259

第十二章 神经营养因子259

The Family of Neurotrophic Factors260

神经营养素家族260

Ciliar Neurotrophic Factors269

睫状神经营养因子269

Astroglia-Derived Neuropholic Factors272

胶质细胞系源性神经营养因子272

已知的生长因子和细胞因子273

Known Growth Factors and Cytokines273

Neurotrophic Factors and Neural Degenerative Disease279

神经营养因子与神经变性疾病279

第十三章 中枢神经系统的可塑性284

Chapter 13 Plasticity of Central Nervous System284

视神经的可塑性285

Plasticity of Optic Nerve285

Plasticity of Spinal Cord297

脊髓的可塑性297

Chapter 14 Dependence of the Developing Nervous System on Nutrition and Hormones and Related Questio304

第十四章 神经系统发育对激素与营养的依赖性及其他有关问题304

Dependence of the Developing Nervous System on Nutrition and Hormones305

神经系统发育对激素与营养的依赖性305

Nitric Oxide and the Development and Regeneration of Nervous System314

NO与神经系统的发育及再生314

Transmitter Development of Neurons in Central Nervous System325

中枢神经元的递质发育325

学习、记忆与脑发育336

Learning, Memory and Brain Development336

Chapter 15 Transplantation and the Development and Regeneration of Central Nervous System348

第十五章 脑内移植与中枢神经系统的发育再生348

脑内移植研究的历史及现状349

Historical Orientation of Transplantation349

Functional Mechanisms of Transplantation350

脑内移植物产生功能效应的机理350

Transplantation of Nerve Tissue and the Development and Regeneration of Central Nervous System353

神经组织移植与中枢神经发育再生353

Recovery of Central Nervous Degenerative Disease by Transplantation of Nerve Tissue356

神经组织移植修复中枢神经退行性疾病的研究356

Chapter 16 Developing Nervous System and Tumor370

第十六章 神经系统发育与肿瘤370

Similarity of Fetus Development and Tumorgenesis371

胚胎发育与肿瘤的相似性371

Etiology and Etiopathogeneis Mechanism of Tumor374

肿瘤的病因及致癌机理374

Oncogene, Anti-Oncogene and Tumorgenesis376

癌基因、抑癌基因与肿瘤发生376

Sort and Physiological Function of Oncogene378

癌基因的种类及生理功能378

Oncogenes Related to the Development and Differention of Nervous System380

与神经系统分化发育有关的癌基因380

Genetic Tumor of the Centeral Nervous System Retinal Blastoma381

神经系统遗传性肿瘤视网膜母细胞瘤381

Other Tumors Related Fetus Development382

神经系统其他的与胚胎发生有关的肿瘤382

Introduction384

Chapter 17 Methodology of Studying Tissue Development and Differentiation384

第十七章 研究组织发育分化的一些实验技术384

概述384

Culture of Mouse Fetus after Transplantation385

植入后小鼠胚胎的培养385

Culture of Neural Plate, Crest, and Neural Tuble390

神经板、神经嵴和神经管的培养390

Subrenal Capsule Embryo Heterotopic Transplantation392

肾被膜下间隙胚胎异位移植技术392

Eye Anterior Heterotopic Transplantation393

眼前房胚胎异位移植技术393